Stockholm Uppsala Pharmacometrics (SUP)
Semi-mechanistic models developed based on PK and/or PD data
A semi-mechanistic model in the pharmacometric domain typically borrows structure from the system it describes to such an extent that, at least some, parameters can be given physiological/pharmacological meaning. The model parameters are typically determined from the experimental data even if priors, either weak or strong, can be used for some of the parameters. Familiar examples are the Friberg model for myelosuppression and the target-mediated drug disposition models.”
Stockholm Uppsala Pharmacometrics (SUP)